Tag: medicine

Linking Size and Origin in Droplets
Respiratory diseases like measles, flu, tuberculosis, and COVID-19 are all transmitted by droplets. Some are tiny and airborne, capable of traveling long distances. Other drops are larger and only capable of traveling short distances. A new review paper consolidates what we know about these droplets and categorizes them by size and origin.
It turns out that a droplet’s size can tell us where it originated in the body. The largest type of droplets come from our mouths, lips, and tongues. Some form from filaments of saliva that stretch across our mouths and burst during exhalation. Others originate in our nasal passages where a sneeze can destabilize the mucus film there. These types of droplets are best suited to transmitting diseases that reside in the upper respiratory tract. Coughing, sneezing, singing, and speaking all produce these droplets, but breathing does not.
In contrast, the smallest classes of droplets come from the bronchial passages of the lungs, where films form after exhalation closes a passage. When we inhale again, the passage reopens, the film breaks up, and tiny droplets flow further into the lungs before getting exhaled. Breathing alone is enough to create and spread these tiny droplets, which are well-suited to spreading diseases that reside deep in the lungs, like tuberculosis.
In between these extremes are medium-sized droplets created from movement around our vocal cords. The formation mechanism for these droplets is least understood, but they are connected to breathing, coughing, speaking, singing, and so on.
Ultimately, understanding the mechanics of disease transmission is about knowing how to best prevent transmission. Knowing the size of droplets responsible for transmission lets us prioritize responses that work. For example, if large droplets are the primary transmission mechanism, loose-fitting masks and face masks will stop the spread. But for smaller droplets, ventilation measures and well-fitted N-95 respirators are the better choice. (Image credit: Anton; research credit: M. Pöhlker et al.; via APS Physics)
November 22, 2023
EpiPen in Action
Researchers are hard at work developing needle-free alternatives to injection, but devices like the EpiPen — used in anaphylactic emergencies for food and insect allergies — aren’t going anywhere yet. In this Slow Mo Guys video, they show what happens when an EpiPen fires into ballistic gel.
An EpiPen’s needle is extremely narrow and about 15 millimeters long. It enters the gel (and presumably the human body) at a modest speed of ~6 m/s, releases the medication, and retracts. Despite its relatively slow speed, the needle is visibly blunted after use (and, no, the EpiPen is not reusable, for this and other reasons).
Injections like this may be tough for some people to see, but as Dan’s mother attests, they’re absolutely life-saving for the patients that need them. (Video and image credit: The Slow Mo Guys)
July 5, 2023
Gathering Safely
One effect of the COVID-19 pandemic is a renewed interest in the physics of disease transmission and what measures can protect us from airborne respiratory illnesses. This recent study looks at how meetings — whether in classrooms, conferences, or care facilities — can transmit infections. Their mathematical model is able to handle many variables — room size, number of people, length of meeting, breaks between sessions, masking, ventilation, and so on. Without prescribing any one policy, the authors aim to inform decision makers so that they can choose what methods (testing, masking, ventilation, etc.) work best for their event.
That said, they find that ventilation and periodic breaks between meetings are highly effective in reducing a room’s viral load. Leaving enough time between sessions for ventilation to clear the room was as effective (or more effective) than masking and moderate isolation of those infected. Tools like these are vital in enabling gatherings that keep participants safe. (Image credit: Product School; research credit: A. Dixit et al.; submitted by Kam-Yung Soh)
June 27, 2023
Disease and Placental Flows
The human placenta functions as a life-support system for a growing fetus. Despite its frisbee-like appearance, the organ is packed with nearly 10 square meters of blood vessels. On the fetal side, these blood vessels form villous trees where diffusion across the placental boundary exchanges molecules with the maternal blood that fills the space between villous trees. This setup allows oxygen, glucose, carbon dioxide and other key chemicals to cross between the parent and fetus while (ideally) keeping diseases out.
Views of the placenta. Beige areas show the intervillous space where maternal blood flows while pink areas show villous trees where exchanges between the fetus and mother take place. The first three images show a) preeclamptic, b) normal, and c) diabetic placentas. The final image d) shows a 3D view of placental tissue taken with x-ray tomography.
But when diseases directly affect the structure of the placenta, flow to the fetus gets disrupted. The image above shows cross-sections of placental tissues, with villous trees marked in pink, under (a) preeclamptic, (b) normal, and (c) diabetic conditions. Preeclampsia is associated with reduced density of villous trees, which restricts the amount of nutrients a fetus receives and can lead to reduced growth or stillbirth. In contrast, with gestational diabetes villous trees can proliferate, causing a high resistance to flow that also affects exchanges.
For more on the complex physics of the placenta, check out this article from Physics Today. (Image credit: sketch – L. da Vinci, placentas – A. Clark et al.; see also A. Clark et al.)
June 21, 2023
Walking in the Wake of a Cylinder
A cylinder in a flow produces a series of alternating vortices known as a von Karman vortex street. Changing the flow speed and rotating the cylinder both allow researchers to tune the frequency of these shed vortices. What happens to an object in the wake?
For a simple hydrofoil tethered to the cylinder, the object wends back and forth along the vortices. But when that hydrofoil sits at the end of a double-pendulum, something very interesting happens. The whole apparatus follows a consistent trajectory similar to a human walking gait. Researchers are using this motion to build a robot that will help physical therapy patients regain a natural walking style. (Image and video credit: A. Carleton et al.)
May 8, 2023
Breaking Clots With Sound
Clots that block blood flow away from the brain are one of the most common causes of strokes for younger people. If caught early, anticoagulants can sometimes resolve the issue, but the treatment fails in 20-40% of cases. Now researchers are investigating a new ultrasound technique capable of quickly and effectively removing these clots.
An illustration of the vortex ultrasound technique breaking up a blood clot.
The group attached a 2 x 2 array of ultrasound transducers to the tip of a catheter like those doctors feed through blood vessels in other interventions. The offset between each ultrasound transducer creates a vortex-like flow when the array is activated. The helical wavefront creates shear stress along the clot’s face, helping to break it up faster. In one test, the new technique broke up a clot and completely restored flow in just 8 minutes. Pharmaceutical treatments take at least 15 hours and average closer to 29 hours.
The team is moving forward to animal trials next and hope, with success there, to bring the technique to clinical studies. (Image credit: abstract – C. Josh, illustration – X. Jiang and C. Shi; research credit: B. Zhang et al.; via Physics World)
March 28, 2023
Toilet Plumes
Toilet flushes are gross. We’ve seen it before, though not in the same detail as this study. Here, researchers illuminate the spray from the flush of a typical commercial toilet, like those found in many public restrooms. They found that flushing generates a plume of droplets that reaches 1.5 meters in under 8 seconds, producing many thousands of droplets across a range of sizes.
The experiments were conducted in a ventilated lab space, and the flushes involved only clean water — no fecal matter or toilet paper — so they don’t perfectly mimic the confines of a public toilet stall. But the implications are still pretty gross. Without a lid to contain the flush’s spray, these energetic toilets are spraying droplets capable of carrying COVID, influenza, and other nastiness all over our bathrooms. (Image and research credit: J. Crimaldi et al.; via Gizmodo)
January 19, 2023
Sound Makes Stickier Bandages
Keeping wounds safe and clean is hard when bandages are so prone to coming off. A team of researchers may have found a solution, though, using ultrasound to enhance adhesion. For their technique, they applied a layer of adhesive primer to the skin and covered it with a hydrogel bandage. Then they used an ultrasound transducer to generate cavitation bubbles in the primer. As the bubbles grew and collapsed, the primer and hydrogel pulled toward the tissue, creating adhesive bonds up to 100 times greater than without ultrasound. The extra adhesion had staying power, too, with between two and ten times more fatigue resistance than the bandage and adhesive alone. The researchers hope their technique will aid tissue repair, wound management, and attaching wearable electronics. (Image and research credit: Z. Ma et al.; via Physics World)
November 17, 2022
Inside a Coronavirus Aerosol
This is a glimpse inside a tiny aerosol droplet with a single SARS-CoV-2 coronavirus inside it. The numerical simulation required a team of 50 scientists, 1.3 billion atoms, and the second most powerful supercomputer in the world. By simulating every atom, the researchers hope to observe what happens to a coronavirus in these micron-sized, long-lasting droplets. Does the virus survive? How do variants fare?
Their simulation shows that the positive charge of the coronavirus’s spike proteins helps attract mucins that shield the virus and protect it from the droplet interface where evaporation could destroy it. Variants like Delta and Omicron have even more positive charge to their spike proteins, giving themselves a better cloak of mucins and potentially making them all the more infectious. Definitely check out the full New York Times write-up for more spectacular visualizations from the work. (Image and research credit: R. Amaro et al.; via NYTimes; submitted by Kam-Yung Soh)
January 10, 2022
Better Inhalers Through CFD
As levels of air pollution rise, so does the incidence of pulmonary diseases like asthma. Treatments for these diseases largely rely on inhalers containing drug particles that need to be carried into the small bronchi of the lungs. To better understand how the process works, researchers used computational fluid dynamics to simulate how air and particles travel through the human respiratory tract.
The team found that larger particles tended to get stuck in the mouth instead of making it down into the lungs. This problem was made worse at high inhalation rates because the particles’ inertia was too large for them to make the sharp turn down into the trachea. In contrast, smaller particles could travel down into the lungs and into the smaller branches there before settling. The authors concluded that inhalers should use fine drug particles to maximize delivery into the lungs. They also note that adjusting inhalers to deliver more medication to the lungs may also lower the overall price because less of the dosage gets wasted in the patient’s mouth.
Of course, the study’s results also serve as a warning about the dangers of air pollution from fine particulates. Here in Colorado, our summers are punctuated with wildfire smoke, much of it in the form of tiny particles about the same size as the drug particles in this study. If fine drug particles are effective at making it into the smaller branches of our lungs, so are those pollutants. That’s a good reason to stay inside in smoky conditions or use a high-quality N-95 mask while out and about. (Image credit: coltsfan; research credit: A. Tiwari et al.; via Physics World; submitted by Kam-Yung Soh)
October 21, 2021