FYFD

Tag: medicine

  • Better Inhalers Through CFD

    Better Inhalers Through CFD

    As levels of air pollution rise, so does the incidence of pulmonary diseases like asthma. Treatments for these diseases largely rely on inhalers containing drug particles that need to be carried into the small bronchi of the lungs. To better understand how the process works, researchers used computational fluid dynamics to simulate how air and particles travel through the human respiratory tract.

    The team found that larger particles tended to get stuck in the mouth instead of making it down into the lungs. This problem was made worse at high inhalation rates because the particles’ inertia was too large for them to make the sharp turn down into the trachea. In contrast, smaller particles could travel down into the lungs and into the smaller branches there before settling. The authors concluded that inhalers should use fine drug particles to maximize delivery into the lungs. They also note that adjusting inhalers to deliver more medication to the lungs may also lower the overall price because less of the dosage gets wasted in the patient’s mouth.

    Of course, the study’s results also serve as a warning about the dangers of air pollution from fine particulates. Here in Colorado, our summers are punctuated with wildfire smoke, much of it in the form of tiny particles about the same size as the drug particles in this study. If fine drug particles are effective at making it into the smaller branches of our lungs, so are those pollutants. That’s a good reason to stay inside in smoky conditions or use a high-quality N-95 mask while out and about. (Image credit: coltsfan; research credit: A. Tiwari et al.; via Physics World; submitted by Kam-Yung Soh)

  • Microjets and Needle-Free Injection

    Microjets and Needle-Free Injection

    Some people don’t mind needles, and others absolutely detest them. But to replace needles with needle-free injections, we have to understand how high-speed microjets pass through skin. Given skin’s opacity, that’s tough, so researchers are instead using droplets as a model. If we can understand the dynamics of a microjet passing through different kinds of droplets, getting jets of medicine into arms becomes easier.

    Researchers found that jets passed completely through a droplet if they impacted above a critical velocity. For Newtonian droplets, the jet creates a cavity and shoots straight through because the inertia of the impact outweighs the countering force of surface tension. But with viscoelastic drops, the jet goes through, slows down, and gets sucked back into the droplet. In this case, the combination of surface tension and viscoelasticity can, eventually, overpower the jet’s inertia. (Image, research, and submission credit: M. Quetzeri-Santiago et al.)

  • How Wombats Make Stackable Feces

    How Wombats Make Stackable Feces

    Wombats are unique among the animal kingdom for their ability to produce cubic feces approximately the size and shape of dice. Researchers found that wombats accomplish this geometric feat thanks to the structure of their intestines, which have bands of differing stiffness that run the full length of their guts. When the intestines contract, the stiffer bands contract first, gradually shaping and sculpting the corners of the feces.

    The results have implications both for manufacturing soft materials and for human health. One of the early effects of colon cancer is a stiffening of portions of the intestine; that means that doctors may be able to use changes in the shape of a patient’s feces as a warning sign for diagnosis. (Image and research credit: P. Yang et al.; video credit: Royal Society of Chemistry; via Gizmodo)

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    Slow Motion Speech

    Sneezing, coughing, and speaking all produce a spray of droplets capable of spreading COVID-19 and other respiratory illnesses. This Slow Mo Guys video is the latest demonstration in a long line of evidence for why wearing masks in public is such an important part of ending our current public health crisis. Also, I think we can all agree: that sneeze footage is gross. (Image and video credit: The Slow Mo Guys)

  • Droplets From Speaking

    Droplets From Speaking

    Illnesses like COVID-19 can spread through droplets and aerosols produced by coughing, sneezing, or even speaking. New research looks at how regular speech patterns produce a spray of droplets. Researchers found that pronouncing many consonants causes a sheet of saliva to form between the speaker’s lips. That sheet stretches into filaments that then break into a spray of droplets.

    Strong, plosive consonants like /p/ and /b/ create the most droplets (Images 2 and 3), but even milder consonants like /m/ create some (Image 1). Interestingly, the researchers found that wearing lip balm drastically decreased droplet production by altering the saliva sheet formation. Even so, there’s no substitute for wearing a properly fitted mask! (Image credits: masks – K. Grabowska, droplets – M. Abkarian and H. Stone; research credit: M. Abkarian and H. Stone; via APS Physics)

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    A Primer on Blood Pressure

    Some of the most important fluid dynamics goes on every moment inside our bodies. After only a few weeks of gestation, the human heart begins its lifelong task of pumping blood throughout tens of thousands of kilometers’ worth of blood vessels. One of our simplest methods for tracking the health of this critical system is a person’s blood pressure, which measures the forces exerted on our blood vessels as our hearts pump. This video gives a brief primer on blood pressure as well as some of the problems that arise when extended bouts of high blood pressure damage our blood vessels. (Image and video credit: TED-Ed)

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    Ventilation and Respiratory Disease

    In 1977, one passenger with the flu infected 38 people onboard a flight with malfunctioning ventilation. In this video, Dianna digs into the physics of respiratory disease transmission and just why ventilation is so key to preventing it.

    There are three primary modes of transmission for respiratory diseases like influence or SARS-CoV-2: 1) touching an infected surface and then oneself, i.e., self-inoculation; 2) inhaling virus-filled droplets larger than 5 nm; and 3) inhaling virus-filled droplets smaller than 5 nm. That size cut-off may seem a little arbitrary, but it’s how scientists distinguish between droplets that fall quickly to the ground and ones that can persist on buoyant air currents.

    That airborne persistence is one of the reasons ventilation — in other words, replacing the air — is so important. So many people on that 1977 flight got sick because there was no system removing the infected air and bringing in fresh air. For more on the fluid dynamics disease transmission, check out these posts. Curious about those bacterial bubble bursts? I’ve covered that, too. (Video and image credit: Physics Girl)

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    Ultrasound in Medicine

    When you hear the term “ultrasound,” your brain likely jumps to grainy black and white images of unborn babies, but this technology has a lot more medical uses than just that! Ultrasound is used to image many parts of the body — earlier this year, I got to see my own heart in action through an echocardiogram, for example. But the technology has therapeutic uses as well. At higher energies, ultrasound is used to break up kidney stones (through cavitation), treat tremors, and alleviate some sources of pain. To learn more, check out Explore Sound’s page on biomedical acoustics. (Video and image credit: Acoustical Society of America)

  • New Signs of Turbulence in Blood Flow

    New Signs of Turbulence in Blood Flow

    Our bodies are filled with a network of blood vessels responsible for keeping our cells oxygenated and carrying away waste products. In many ways, our blood vessels are tiny pipes, but there’s a crucial difference in the flow they carry: it’s pulsatile. Because the flow is driven by our hearts, rather than a continuous pump, every heartbeat creates a distinct cycle of acceleration and deceleration in the flow. And new research has found that this cycle, when combined with curvature or flow restrictions like plaque build-up, can create turbulence in unexpected places.

    Specifically, the researchers found that decelerating pipe flows can develop a helical instability that breaks down into turbulence, even in vessels where purely laminar flow would be expected. In the animations above, you can see the flow slow, develop swirls and then break into turbulence. The flow becomes laminar again as it accelerates, but during that brief bout of turbulence there’s much higher forces on the walls of a blood vessel. Over time, that extra force could contribute to inflammation or even hardening of the arteries. (Image and research credit: D. Xu et al.; via phys.org)

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    How COVID-19 Affects the Lungs

    One of the best known COVID-19 symptoms of this pandemic is difficulty breathing, and while you’ve likely heard a lot about ventilators used to help patients get oxygen, you may not know much about the processes that cause the breathing problems. This video from Deep Look provides a solid overview of the infection route and how lung damage occurs during infection. Perhaps unsurprisingly — this is FYFD, after all — fluid dynamics plays a major role in this process, both under normal conditions and when air sacs in the lungs get damaged by the body’s immune system responding to the virus. (Image and video credit: Deep Look)