Research

Jamming Inside

A Spirostomum ambiguum cell can retract to half its length in milliseconds. How does it do that without destroying its internal structure?

Worm-like Spirostomum ambiguum are millimeter-sized single-cell organisms that live in brackish waters. In milliseconds, these cells can retract to half their original length, generating g-forces greater than a Formula One driver experiences when cornering. How, researchers wondered, do these cells avoid shredding their internal structure with forces that strong?

Spirostomum ambiguum, they found, contain fluid-filled sacs called vacuoles that are entangled with the folds of a membrane-like structure called the endoplasmic reticulum. The researchers constructed a simulated cell, based on the properties of the living ones, and tested it under retraction. Without the endoplasmic reticulum, the insides of their model acted like a liquid, with vacuoles moving past one another readily. That’s not good for staying alive since swapping positions can disrupt bodily functions.

An artificially-colored micrograph highlights the different structures inside Spirostomum ambiguum. The red strings are a membrane-like endoplasmic reticulum entangled between yellow, fluid-filled vacuoles.
An artificially-colored micrograph highlights the different structures inside Spirostomum ambiguum. The red strings are a membrane-like endoplasmic reticulum entangled between yellow, fluid-filled vacuoles.

With the vacuoles connected by a model endoplasmic reticulum, the cell’s insides acted more like a solid during retraction. The vacuoles deformed but fewer of them traded places, instead jamming together to prevent rearrangement. Mimicking this structure at a larger scale, the team suggests, could enable new types of shock absorbers. (Image and research credit: R. Chang and M. Prakash; via APS Physics)

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