With small droplets, gravity usually has little effect compared to surface tension. An evaporating water droplet holds its spherical shape as it evaporates. But the story is different when you add proteins to the droplet, as seen in this recent study.

As a protein-doped droplet sitting on a surface evaporates, it starts out spherical, like its protein-free cousin. But, as the water evaporates, it leaves proteins behind, gradually increasing their concentration. Eventually, they form an elastic skin covering the drop. As water continues to evaporate, the droplet flattens.

In contrast, a hanging droplet with proteins takes on a wrinkled appearance once its elastic skin forms. The key difference, according to the model constructed by the authors, is the direction that gravity points. Despite these droplets’ small size, gravity makes a difference! (Image, video, and research credit: D. Riccobelli et al.; via APS Physics)